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- Title
Adverse Pregnancy Outcomes and Rheumatoid Arthritis: a Retrospective Matched Cohort Study.
- Authors
Sadeghi, Alireza; Rostami, Mina; Nasiri, Nazila; Hatami, Robabeh; Moghaddam, Arezoo Karimi; Moghaddam, Zhaleh Karimi; Zeraatchi, Alireza
- Abstract
Background & Objective: Rheumatoid Arthritis (RA) is an autoimmune-driven chronic systemic inflammatory disease. It could result in miscarriage, preeclampsia, and preterm labor, among other unfavorable pregnancy outcomes. Thus, this study was conducted to investigate the adverse pregnancy outcomes in pregnant women with RA. Materials & Methods: Two cohorts of pregnant women with and without RA referred to the Ayatollah Mousavi Hospital's Gynecology and Obstetrics Clinic in Zanjan, Iran, during 2019-2020 were enrolled in a retrospective matched cohort study. Using their medical records, each participant completed a checklist of study variables. We used binary Logistic regression, chi-square test, Analysis of Variance, and independent samples t-test to analyze data using SPSS v.23. Results: The study included 280 pregnant women. The mean age of the RA and control group (pregnant women without RA) was 32.4 ± 6.6 and 29.5 ± 6.7 years, respectively. The most prevalent adverse outcome was spontaneous abortion (54, 19.28%), which was significantly higher in the RA group (25% vs. 13.6%, P= 0.015). Cesarean section (24.3% vs. 10.7%, P= 0.003) and low birth weight (LBW) were both significantly higher in the RA group (15% vs. 5%, P= 0.005). RA increased the probability of spontaneous abortion, cesarean section, and LBW by more than 1.3 (odds ratio, 1.38; 95% CI, 0.45-5.46; P= 0.017), 2.2 (odds ratio, 2.24; 95% CI, 1.29- 6.54; P =0.004), and 2.6 (odds ratio, 2.67; 95% CI, 1.86-7.05; P= 0.008) times, respectively. Conclusion: Pregnant women with RA are more likely to experience spontaneous abortion, cesarean section, and having LBW infants comparing to pregnant women without RA.
- Subjects
IRAN; RISK factors in premature labor; RISK assessment; MISCARRIAGE; CESAREAN section; T-test (Statistics); RHEUMATOID arthritis; LOGISTIC regression analysis; INTERVIEWING; PREGNANT women; PREGNANCY outcomes; RETROSPECTIVE studies; DESCRIPTIVE statistics; CHI-squared test; PERINATAL death; LONGITUDINAL method; LOW birth weight; ODDS ratio; HYPERTENSION in pregnancy; ANALYSIS of variance; MEDICAL records; ACQUISITION of data; PREGNANCY complications; DATA analysis software; CONFIDENCE intervals; EDUCATIONAL attainment; DISEASE risk factors; DISEASE complications; PREGNANCY
- Publication
Journal of Advances in Medical & Biomedical Research, 2023, Vol 31, Issue 149, p549
- ISSN
2676-6264
- Publication type
Article
- DOI
10.30699/jambs.31.149.549