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- Title
CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.
- Authors
Wong, Athena W.; Brickey, W. June; Taxman, Debra J.; van Deventer, Hendrick W.; Reed, William; Jian Xin Gao; Pan Zheng; Yang Liu; Ping Li; Blum, Janice S.; McKinnon, Karen P.; Ting, Jenny P-Y
- Abstract
The major histocompatibility complex (MHC) class II transactivator (CIITA) is the 'master coactivator' of MHC class II genes. To identify new targets of CIITA, we analyzed cDNA microarrays of dendritic cells (DCs) from CIITA-deficient, MHC class II-deficient and control mice. We found the semaphorin receptor plexin-A1 was expressed in DCs, but not in other immune cells, and was strongly induced by CIITA. RNA interference by short hairpin RNA specific for plexin-A1, but not a single-nucleotide mutant, greatly reduced plexin-A1 expression and T cell stimulation by protein- or peptide-antigen-pulsed DCs.Plexin-A1 is not required for peptide binding to MHC. These data indicate involvement of plexin-A1 in T cell-DC interactions but not antigen processing or binding.
- Subjects
MAJOR histocompatibility complex; DENDRITIC cells; T cells; HISTOCOMPATIBILITY; CELL communication
- Publication
Nature Immunology, 2003, Vol 4, Issue 9, p891
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni960