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- Title
BOTULINUM TOXIN: FROM THE NATURAL CAUSE OF BOTULISM TO AN EMERGING THERAPEUTIC IN VETERINARY MEDICINE.
- Authors
Šoštarić, Petra; Članjak-Kudra, Enida; Smajlović, Ahmed; Matak, Ivica
- Abstract
Botulinum toxins are one of the most potent biological toxins known. They cause botulism in wildlife and livestock, and thus, are regarded as a problem in veterinary medicine. On the other hand, use of purified low dose pharmaceutical grade botulinum toxin serotype A (BoNT-A) in different human clinical implications such as movement, autonomic disorders and pain conditions have expanded in the last 30-40 years based on its long-lasting effects and a good safety profile. Despite that, its use in veterinary practice is lagging far behind the already well-established use in humans. BoNT-A is not licensed for use in any veterinary medical condition, and, overall, there are only a few clinical trials and several case studies, the most notable being case reports and limited clinical studies of osteoarthritis and perioperative pain in dogs, lameness in horses as well as the spasticity treatment in cats. Indications for BoNT-A use in veterinary medicine happen to be very similar when compared to indications in humans, which is not surprising due to pathophysiological similarities. This warrants further clinical research of novel indications of BoNT-A in veterinary medicine.
- Subjects
VETERINARY medicine; BOTULISM; TOXINS; BOTULINUM A toxins; BOTULINUM toxin; LAMENESS in horses
- Publication
Veterinaria, 2022, Vol 71, Issue 2, p153
- ISSN
0372-6827
- Publication type
Article
- DOI
10.51607/22331360.2022.71.2.153