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- Title
Miliary Tuberculosis in a Patient With Ulcerative Colitis Treated With Tofacitinib.
- Authors
Verma, Shruti; Singh, Arshdeep; Kakkar, Chandan; Tripathi, Ashish; Midha, Vandana; Sood, Ajit
- Abstract
Immunosuppression with tumor necrosis factor-alpha inhibitors and tofacitinib is a risk factor for reactivation of latent tuberculosis (TB) and the development of active TB. We report a case of miliary TB in a patient on treatment with tofacitinib for active ulcerative colitis. By week 4 of therapy, a clinical response was achieved. Subsequently, although being on treatment, the patient started having fever with night sweats and myalgias. The investigative workup revealed pulmonary miliary TB. Tofacitinib was withdrawn, and antitubercular therapy was initiated. The patient responded, both clinically and radiologically, to the antitubercular therapy. This case report highlights the importance of screening for latent TB in patients receiving tofacitinib.
- Subjects
ULCERATIVE colitis; FEVER; INFLAMMATORY bowel diseases; ANTI-inflammatory agents; IMMUNOSUPPRESSION; LATENT tuberculosis; MAGNETIC resonance imaging; JANUS kinases; WEIGHT loss; NEUROTRANSMITTER uptake inhibitors; COMPUTED tomography; SENSITIVITY &; specificity (Statistics); ANOREXIA nervosa
- Publication
ACG Case Reports Journal, 2023, Vol 10, Issue 6, p1
- ISSN
2326-3253
- Publication type
Article
- DOI
10.14309/crj.0000000000001066