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- Title
Lack of association between GABRA3 and unipolar affective disorder: a multicentre study.
- Authors
Massat, I.; Souery, D.; Del-Favero, J.; Oruc, L.; Jakovljevic, M.; Folnegovic, V.; Adolfsson, R.; Kaneva, R.; Papadimitriou, G.; Dikeos, D.; Jazin, E.; Milanova, V.; Van Broeckhoven, C.; Mendlewicz, J.
- Abstract
Available data on gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in the brain GABAergic system activity contributes to vulnerability to affective disorders (AD), including bipolar disorder (BPAD) and unipolar disorder (UPAD). The localization of the ±3 subunit GABA receptor (GABRA3) gene in Xq28, a region of interest for BPAD suggests that GABRA3 may be a relevant candidate gene. In the present study, we tested the genetic contribution of the GABRA3 dinucleotide polymorphism in a European multicentre UPAD case-control sample [UPAD (n = 106), controls (n = 212)]. Our negative results suggest that GABRA3 does not confer susceptibility nor is it in linkage disequilibrium with another close gene involved in the genetic aetiology of UPAD.
- Publication
International Journal of Neuropsychopharmacology, 2001, Vol 4, Issue 3, p273
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1017/S1461145701002449