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- Title
Subcortical Vascular Dementia Biomarker Pattern in Mild Cognitive Impairment.
- Authors
Bjerke, Maria; Andreasson, Ulf; Rolstad, Sindre; Nordlund, Arto; Lind, Karin; Zetterberg, Henrik; Edman, Åke; Blennow, Kaj; Wallin, Anders
- Abstract
Background: Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies. Aim: The aim of the study was to assess whether baseline CSF hyperphosphorylated tau (P-tau), total tau (T-tau), amyloid β 1–42 (Aβ42) and neurofilament light (NF-L) in patients with MCI could predict subcortical vascular dementia (SVD) and Alzheimer’s disease (AD) at follow-up. Methods: Biomarker levels were assessed by Luminex xMAP technology and ELISA. Results: Increased baseline concentrations of NF-L significantly separated MCI-SVD from stable MCI. The MCI-SVD patients were inseparable from stable MCI but separable from patients developing AD (MCI-AD) on the basis of Aβ42, T-tau and P-tau181 levels. Conclusion: A combination of the biomarkers Aβ42, T-tau, P-tau181 and NF-L has the potential to improve the clinical separation of MCI-SVD patients from stable MCI and MCI-AD patients. Copyright © 2009 S. Karger AG, Basel
- Subjects
COGNITIVE ability; ETIOLOGY of diseases; CEREBROSPINAL fluid; BIOMARKERS; CYTOPLASMIC filaments; ALZHEIMER'S disease
- Publication
Dementia & Geriatric Cognitive Disorders, 2009, Vol 28, Issue 4, p348
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000252773