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- Title
Morphological Changes in Intervertebral Disks of the Caudal Part of the Rat Spine after Permanent and Temporary Asymmetrical Compression-Distraction.
- Authors
Grigorovskii, V.; Khizhnyak, M.; Gafiichuk, Yu.
- Abstract
Experiments on 44 rats addressed the histological characteristics of tissue injury and repair in segments of the caudal part of the spine after prolonged permanent and temporary (with subsequent relaxation of the tail) asymmetrical compression-distraction (ASCD). The results showed that permanent ASCD of the tail led to complex structural changes which were very stable and did not disappear after release of ASCD and relaxation. Cell necrosis was seen in the annulus fibrosus (AF), with stretching of the lamellae of the AF and separation from the epiphyses on the side of distraction, and crushing and fiber separation of the collagen lamellae of the AF on the compression side, along with proliferation of chondrocytes around necrotic foci. The nucleus pulposus (NP) showed increases in the number of necrotized chordal cells. Relaxation after temporary ASCD led to decreases in the extent, but not complete elimination, of signs of injury. There were changes in AF thickness, frequency of foci of necrosis, and areas of separation of collagen lamellae, as well as displacement of the NP on the distraction side.
- Subjects
INTERVERTEBRAL disk abnormalities; MORPHOLOGY; DISTRACTION; TISSUE wounds; NECROSIS; LABORATORY rats; CELL proliferation
- Publication
Neuroscience & Behavioral Physiology, 2014, Vol 44, Issue 7, p784
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-014-9984-4