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- Title
Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea.
- Authors
Foster, Glen E.; Poulin, Marc J.; Hanly, Patrick J.
- Abstract
Obstructive sleep apnoea (OSA) has been implicated as a risk factor for the development of hypertension, stroke and myocardial infarction. The main cause of cardiovascular and cerebrovascular disease in OSA is thought to be exposure to intermittent hypoxia, which can lead to oxidative stress, inflammation, atherosclerosis, endothelial dysfunction and hypertension. These proposed mechanisms have been drawn from basic research in animal and human models of intermittent hypoxia in addition to clinical investigation of patients with OSA. This review outlines the association between OSA and vascular disease, describes basic mechanisms that may be responsible for this association and compares the results from studies of OSA subjects with those in experimental models of intermittent hypoxia.
- Subjects
HYPOXEMIA; SLEEP apnea syndromes; SLEEP disorders; HYPERTENSION; MYOCARDIAL infarction; CARDIOVASCULAR diseases; CEREBROVASCULAR disease
- Publication
Experimental Physiology, 2007, Vol 92, Issue 1, p51
- ISSN
0958-0670
- Publication type
Article
- DOI
10.1113/expphysiol.2006.035204