We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients.
- Authors
Arhin, Nina D.; Shen, Chan; Bailey, Christina E.; Matsuoka, Lea K.; Hawkins, Alexander T.; Holowatyj, Andreana N.; Ciombor, Kristen K.; Hopkins, Michael B.; Geiger, Timothy M.; Kam, Audrey E.; Roth, Marc T.; Lebeck Lee, Cody M.; Lapelusa, Michael; Dasari, Arvind; Eng, Cathy
- Abstract
Background: The incidence of colorectal cancer in adults younger than age 50 has increased with rates expected to continue to increase over the next decade. The objective of this study is to examine the survival benefit of surgical resection (primary and/or metastatic) versus palliative therapy in this patient population. Methods: We identified 6708 young adults aged 18–45 years diagnosed with metastatic colorectal cancer (mCRC) from 2004 to 2015 from the SEER database. Overall survival (OS) was analyzed using Kaplan–Meier estimation, log rank test, and multivariate Cox proportional hazards model. Results: Sixty‐three percent of patients in our study underwent primary tumor resection (PTR), with 40% undergoing PTR alone and 23% undergoing both resection of primary disease and metastasectomy. The median OS for patients who underwent both PTR and metastasectomy was 36 months, compared to 13 months for those who did not receive any surgical intervention. The multivariate analysis showed significant OS benefit of receiving both PTR and metastasectomy (HR 0.34, 95% CI: 0.31–0.37, p < 0.001) compared to palliative therapy. Undergoing PTR only and metastasectomy only were also associated with improved OS (HR 0.46, 95% CI: 0.43–0.49, p < 0.001 and HR 0.64, 95% CI: 0.55–0.76, p < 0.001, respectively). Conclusion: This is the largest observational study to evaluate survival outcomes in young‐onset mCRC patients and the role of surgical intervention of the primary and/or metastatic site. Our study provides evidence of statistically significant increase in OS for young mCRC patients who undergo surgical intervention of the primary and/or metastatic site.
- Subjects
COLORECTAL cancer; SURVIVAL rate; YOUNG adults; CANCER patients; OVERALL survival; SURGICAL excision
- Publication
Cancer Medicine, 2021, Vol 10, Issue 13, p4269
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.3940