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- Title
Cardiac tamponade in a pediatric renal transplant recipient on sirolimus therapy.
- Authors
Uyen Truong; Moon-Grady, Anita J.; Butani, Lavjay
- Abstract
Truong U, Moon-Grady AJ, Butani L. Cardiac tamponade in a pediatric renal transplant recipient on sirolimus therapy. Pediatr Transplantation 2005: 9: 541–544. © 2005 Blackwell Munksgaard Because of its lack of nephrotoxicity, the use of sirolimus, as an immunosuppressive agent, has increased considerably in solid-organ transplant (Tx) recipients. With its increased use, Tx professionals are encountering a variety of previously unreported side-effects such as angioedema and interstitial pneumonitis. We describe here the case of a pediatric renal Tx recipient who, while receiving sirolimus, developed a large pericardial effusion requiring pericardiocentesis. An extensive workup for an infectious etiology was performed; the only positive result was isolation of adenovirus type 2 from the patient's stool specimen. Following sirolimus dose reduction this child's effusion stabilized and has not recurred. The purpose of this report is to advise health-care professionals caring for Tx recipients about this potentially life-threatening complication associated with sirolimus. The role of adenovirus, if any, in contributing to the development of our patient's pericardial effusion is discussed herein.
- Subjects
CARDIAC tamponade; RAPAMYCIN; LIVER transplantation; PEDIATRICS; TRANSPLANTATION of organs, tissues, etc. in children; DRUG therapy
- Publication
Pediatric Transplantation, 2005, Vol 9, Issue 4, p541
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/j.1399-3046.2005.00323.x