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- Title
Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review.
- Authors
Yuwei Jiang; Wenjun Dang; Hong Nie; Xiangying Kong; Zhimei Jiang; Jin Guo
- Abstract
This systematic review aims to offer an updated understanding of the relationship between omega-3 supplementation and/or vitamin D and autism spectrum disorders (ASD). The databases PubMed, Cochrane Library, Web of Science, EMBASE, CINAHL, Vip, CNKI, Wanfang, China Biomedical Database databases were searched using keywords, and relevant literature was hand-searched. Papers (n  =  1,151) were systematically screened and deemed eligible since 2002. Twenty clinical controlled studies were included in the final review. The findings were analyzed for intervention effects focusing on the core symptoms of ASD, included social functioning, behavioral functioning, speech function and biomarkers changes. The review found that the effects of omega-3 supplementation on ASD were too weak to conclude that core symptoms were alleviated. Vitamin D supplementation improved core symptoms, particularly behavioral functioning, however, the results of the literatures included in this study were slightly mixed, we cannot directly conclude that vitamin D supplementation has a beneficial effect on a specific symptom of ASD, but the overall conclusion is that vitamin D supplementation has a positive effect on behavioral functioning in ASD. Omega-3 and vitamin D combination supplementation has a good combined effect on social and behavioral outcomes in patients with ASD.
- Subjects
AUTISM spectrum disorders; UNSATURATED fatty acids; OMEGA-3 fatty acids; VITAMIN D; DIETARY supplements
- Publication
Frontiers in Psychiatry, 2023, p1
- ISSN
1664-0640
- Publication type
Article
- DOI
10.3389/fpsyt.2023.1238973