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- Title
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2?Cyclin A.
- Authors
Meraldi, Patrick; Lukas, Jiri; Fry, Andrew M.; Bartek, Jiri; Nigg, Erich A.
- Abstract
Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division. In a manner highly reminiscent of DNA replication, the centrosome must be duplicated once, and only once, in each cell cycle. How centrosome duplication is regulated and coordinated with other cell-cycle functions remains poorly understood. Here, we have established a centrosome duplication assay using mammalian somatic cells. We show that centrosome duplication requires the activation of E2F transcription factors and Cdk2 -- cyclin A activity.
- Subjects
CENTROSOMES; CHROMOSOMES; CELL division; CELL cycle; DNA replication
- Publication
Nature Cell Biology, 1999, Vol 1, Issue 2, p88
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/10054