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- Title
The habenula is crucial for experience-dependent modification of fear responses in zebrafish.
- Authors
Agetsuma, Masakazu; Aizawa, Hidenori; Aoki, Tazu; Nakayama, Ryoko; Takahoko, Mikako; Goto, Midori; Sassa, Takayuki; Amo, Ryunosuke; Shiraki, Toshiyuki; Kawakami, Koichi; Hosoya, Toshihiko; Higashijima, Shin-ichi; Okamoto, Hitoshi
- Abstract
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
- Subjects
ZEBRA danio; BRACHYDANIO; MAMMALS; GENETICS; AQUATIC mammals
- Publication
Nature Neuroscience, 2010, Vol 13, Issue 11, p1354
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2654