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- Title
Efficacy of Stronger Neo-Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis.
- Authors
Miyake, Kazuhiko; Tango, Toshiro; Ota, Yasuhiko; Mitamura, Keiji; Yoshiba, Makoto; Kako, Makoto; Hayashi, Shigeki; Ikeda, Yusei; Hayashida, Norimasa; Iwabuchi, Shogo; Sato, Yuzuru; Tomi, Toshiaki; Funaki, Naoya; Hashimoto, Naoaki; Umeda, Tomoyuki; Miyazaki, Jun; Tanaka, Katsuaki; Endo, Yasuo; Suzuki, Hiroshi
- Abstract
Background: A daily injection of glycyrrhizin (Stronger Neo-Minophagen C (SNMC) containing 40 mg glycyrrhizin in a 20 mL ampoule) lowers alanine aminotransferase (ALT) levels in patients with chronic viral hepatitis. Methods: The therapeutic effects of intermittent administration of SNMC three times a week for 12 weeks were evaluated and compared between two doses (40 and 100 mL) in a randomized clinical trial. Results: Overall, the therapeutic response was better in the 53 patients allocated 100mL than the 59 who were allocated to have 40mL SNMC (P=0.0243). At the completion of SNMC treatment, ALT levels decreased more extensively in the patients on 100 mL than those on 40 mL SNMC (-29 vs-50% in comparison with the baseline value, P= 0.0002). Minor side-effects occurred in both the patients on 100mL (20%) and those on 40mL (12%), but they did not require any therapies. Conclusions: Intermittent SNMC would be efficient in suppressing ALT levels in patients with chronic viral hepatitis in a dose-dependent manner. Taken along with infrequent and very mild side-effects, longterm intermittent SNMC would benefit patients with chronic hepatitis by maintaining their quality of life with easier compliance.
- Subjects
ANTIVIRAL agents; HEPATITIS treatment
- Publication
Journal of Gastroenterology & Hepatology, 2002, Vol 17, Issue 11, p1198
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1046/j.1440-1746.2002.02876.x