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- Title
Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-Based Chemoradiation Following Resection of Pancreatic Adenocarcinoma.
- Authors
Regine, William F.; Winter, Kathryn A.; Abrams, Ross A.; Safran, Howard; Hoffman, John P.; Konski, Andre; Benson, Al B.; Macdonald, John S.; Kudrimoti, Mahesh R.; Fromm, Mitchel L.; Haddock, Michael G.; Schaefer, Paul; Willett, Christopher G.; Rich, Tyvin A.
- Abstract
This article reports on a controlled medical trial where patients with locally advanced metastatic pancreatic adenocarcinoma were treated with either fluorouracil or gemcitabine chemotherapy following rounds of fluorouracil-based chemoradiation. The study was conducted by the Radiation Therapy Oncology Group, the Eastern Cooperative Oncology Group, and the Southwest Oncology Group. It was designed to see if gemcitabine would improve the cancer patients' survival rates if used in addition to fluorouracil chemoradiation. The results were based on survival and toxicity in patients. The article concludes that gemcitabine did increase patient survival, but the increase was not statistically significant.
- Subjects
ADENOCARCINOMA; CANCER treatment; FLUOROURACIL; CANCER patients; CANCER-related mortality; MEDICAL research; RANDOMIZED controlled trials; RADIATION Therapy Oncology Group (Organization); PANCREATIC cancer
- Publication
JAMA: Journal of the American Medical Association, 2008, Vol 299, Issue 9, p1019
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.299.9.1019