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- Title
Successful Treatment of Adolescents and Young Adults with Philadelphia-Negative Acute Lymphoblastic Leukemia by Novel L-Asparaginase-Intensified Induction Therapy and Cord Blood Transplantation: A Single-Center Decade Report.
- Authors
Kojima, Akira; Yamada, Kazunari; Kajiwara, Koichi; Takeuchi, Yuichi; Matsui, Marina; Tsukada, Masao; Iwama, Kanichi; Kozai, Yasuji; Kodo, Hideki
- Abstract
A novel induction therapy, including intensive L-asparaginase, was designed in 2007 for patients aged <45 years with Philadelphia-negative acute lymphoblastic leukemia (ALL). We analyzed seven <italic>de novo</italic> cases and one case of recurrence who received this treatment. The median age was 21 years (range: 16–35 years). Four patients had T-ALL and the others had B-ALL. All the patients achieved complete remission and proceeded to cord blood transplantation. In the median 72-month follow-up, there were no cases of observed mortality or recurrence. Our results indicate scope for further development of both induction therapy and postremission therapy.
- Subjects
PENNSYLVANIA; CORD blood transplantation; LYMPHOBLASTIC leukemia treatment; ASPARAGINASE; CANCER relapse; TREATMENT effectiveness; DISEASE remission; THERAPEUTICS
- Publication
Journal of Adolescent & Young Adult Oncology, 2018, Vol 7, Issue 3, p389
- ISSN
2156-5333
- Publication type
Article
- DOI
10.1089/jayao.2017.0120