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- Title
Plasmablastic Lymphoma or Plasmablastic Myeloma: A Case of Post-Transplant Lymphoproliferative Disorder.
- Authors
Ramadas, Poornima; Williams, Michael; Duggan, David B.
- Abstract
Plasmablastic lymphomas and plasmablastic myelomas are malignancies with overlapping clinical and pathological features which pose a diagnostic dilemma and are known to be aggressive with a poor outcome. CD38 is a common immunophenotypic maker for both these malignancies and provides a rationale for using daratumumab-based regimes. We describe a 57-year-old male with a history of end-stage renal disease who underwent a deceased-donor renal transplant maintained on chronic immunosuppression who presented with ascites and was found to have abdominal adenopathy and a lytic lesion in the humerus and diagnosed with a post-transplant lymphoproliferative disorder with features intermediate between plasmablastic lymphoma and plasmablastic myeloma. The patient was subsequently treated with a daratumumab-based regime with an excellent response. This case highlights a rare scenario that poses a diagnostic and therapeutic challenge. As there is no standard of care for the treatment of both these malignancies, this case report also describes the use of daratumumab with a good long-term outcome, especially when the pathological distinction between the two entities is difficult.
- Subjects
LYMPHOPROLIFERATIVE disorders; MULTIPLE myeloma; CASTLEMAN'S disease; LYMPHOMAS; CHRONIC kidney failure; DARATUMUMAB
- Publication
Case Reports in Hematology, 2021, p1
- ISSN
2090-6560
- Publication type
Case Study
- DOI
10.1155/2021/4354941