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- Title
Efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives via a non-catalytic one-pot three-component reaction.
- Authors
Lü, Cheng-Wei; Wang, Jia-Jing; Li, Fei; Yu, Shi-Jun; An, Yue
- Abstract
A convenient one-pot multi-component strategy was conducted successfully under catalyst-free conditions employing water and PEG-400 as the efficient and cheap promoting medium. Three types and nearly 50 2-amino-3-cyano-4H-pyran annulated derivatives were synthesized in good to excellent yields by the condensation of a series of aromatic aldehydes with malononitrile and different 1,3-dicarbonyl compounds. Broad substrate scope, systematic characterization, eliminated catalyst, brief reaction time, and simple purification procedure are the best merits in this process. Graphical Abstract:
- Subjects
PYRAN derivatives; CHEMICAL synthesis; PYRAN synthesis; AROMATIC aldehydes; CONDENSATION; MALONONITRILE
- Publication
Research on Chemical Intermediates, 2018, Vol 44, Issue 2, p1035
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-017-3151-9