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- Title
A convenient and efficient method for the synthesis of new 2-(4-amino substituted benzilidine) indanone derivatives.
- Authors
Teimuri-Mofrad, Reza; Nikbakht, Roghaye; Gholamhosseini-Nazari, Mahdi
- Abstract
An efficient and improved process for the synthesis of novel 1-indanones derivatives has been developed. In the first step of the presented new process, 4-bromobenzaldehyde reacts with 5, 6-dimethoxy-2, 3-dihydro-1 H-inden-1-one by N-arylation of corresponding compounds with a variety of aliphatic and aromatic amines to produce a novel category of 1-indanones as the final step. Comparison of this newly designed method with conventional methods show that our method is much more efficient in producing a higher total yield. This innovative synthesis methodology offers several advantages, among which the consumption of inexpensive reagents and the resulting higher total yields of final products are of its remarkable points.
- Subjects
BENZENE compound synthesis; CHEMICAL derivatives; SUBSTITUENTS (Chemistry); AROMATIC amines; ARYLATION; ALIPHATIC amines
- Publication
Research on Chemical Intermediates, 2016, Vol 42, Issue 10, p7501
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-016-2549-0