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- Title
Deriving dose limits for warnings in electronic prescribing systems: statistical analysis of prescription data at University Hospital Birmingham, UK.
- Authors
Coleman JJ; Hodson J; Ferner RE; Coleman, Jamie J; Hodson, James; Ferner, Robin E
- Abstract
<bold>Introduction: </bold>: Electronic decision support can reduce medication errors, and dose-range checking is one element of that support.<bold>Objective: </bold>: The aim of this study was to design an approach to setting upper dose warning limits in electronic prescribing systems where there are historical data on dosing.<bold>Method: </bold>: We used historical data on 56 drug-form combinations for which over 100 prescriptions had been issued between 1 June 2009 and 31 May 2010 in a bespoke electronic prescribing system at University Hospital Birmingham, UK. First, two experts derived dose limits for each drug-form combination, then the drugs were randomly divided into a training set and a test set. A variation of the 'Nearest Rank' approach to estimate statistical limits was used to derive the percentile with the optimal sensitivity and specificity.<bold>Results: </bold>: For the 28 drug-form combinations in the test set, the 86th percentile of dose gave a mean sensitivity of 95.3% and a mean specificity of 97.9% for warning limits, representing the highest reasonable dose; the 96th percentile gave a mean sensitivity of 90.2% and mean specificity of 99.5% for disallow limits, beyond which no dose should be prescribed.<bold>Conclusions: </bold>: Dosing decision support within electronic prescribing systems can be derived by statistical analysis of historical prescription data. We advocate a combined theoretical and statistical derivation of dose checking rules in order to ensure that prescribers are alerted appropriately to potentially toxic doses.
- Publication
Drug Safety, 2012, Vol 35, Issue 4, p291
- ISSN
0114-5916
- Publication type
journal article
- DOI
10.2165/11594810-000000000-00000