We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The World of Oral Cancer and Its Risk Factors Viewed from the Aspect of MicroRNA Expression Patterns.
- Authors
Aghiorghiesei, Ovidiu; Zanoaga, Oana; Nutu, Andreea; Braicu, Cornelia; Campian, Radu Septimiu; Lucaciu, Ondine; Berindan Neagoe, Ioana
- Abstract
Oral cancer is one of the leading causes of death worldwide, with a reported 5-year survival rate of around 50% after treatment. Epigenetic modifications are considered to have a key role in oral carcinogenesis due to histone modifications, aberrant DNA methylation, and altered expression of miRNAs. MicroRNAs (miRNAs) are small non-coding RNAs that have a key role in cancer development by regulating signaling pathways involved in carcinogenesis. MiRNA deregulation identified in oral cancer has led to the idea of using them as potential biomarkers for early diagnosis, prognosis, and the development of novel therapeutic strategies. In recent years, a key role has been observed for risk factors in preventing and treating this malignancy. The purpose of this review is to summarize the recent knowledge about the altered mechanisms of oral cancer due to risk factors and the role of miRNAs in these mechanisms.
- Subjects
ORAL cancer; DISEASE risk factors; RNA regulation; MICRORNA; NON-coding RNA
- Publication
Genes, 2022, Vol 13, Issue 4, p594
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes13040594