We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial.
- Authors
Mantri, Aakash; Köhlmoos, Anika; Schelski, Daniela Stephanie; Seel, Waldemar; Stoffel-Wagner, Birgit; Krawitz, Peter; Stehle, Peter; Holst, Jens Juul; Weber, Bernd; Koban, Leonie; Plassmann, Hilke; Simon, Marie-Christine
- Abstract
Synbiotics modulate the gut microbiome and contribute to the prevention of liver diseases such as metabolic-dysfunction-associated fatty liver disease (MAFLD). This study aimed to evaluate the effect of a randomized, placebo-controlled, double-blinded seven-week intervention trial on the liver metabolism in 117 metabolically healthy male participants. Anthropometric data, blood parameters, and stool samples were analyzed using linear mixed models. After seven weeks of intervention, there was a significant reduction in alanine aminotransferase (ALT) in the synbiotic group compared to the placebo group (−14.92%, CI: −26.60–−3.23%, p = 0.013). A stratified analysis according to body fat percentage revealed a significant decrease in ALT (−20.70%, CI: −40.88–−0.53%, p = 0.045) in participants with an elevated body fat percentage. Further, a significant change in microbiome composition (1.16, CI: 0.06–2.25, p = 0.039) in this group was found, while the microbial composition remained stable upon intervention in the group with physiological body fat. The 7-week synbiotic intervention reduced ALT levels, especially in participants with an elevated body fat percentage, possibly due to modulation of the gut microbiome. Synbiotic intake may be helpful in delaying the progression of MAFLD and could be used in addition to the recommended lifestyle modification therapy.
- Subjects
FECAL analysis; METABOLIC disorders; NON-alcoholic fatty liver disease; PLACEBOS; ADIPOSE tissues; RESEARCH funding; FECES; GUT microbiome; STATISTICAL sampling; BLIND experiment; TREATMENT effectiveness; RANDOMIZED controlled trials; DESCRIPTIVE statistics; BLOOD cell count; SYNBIOTICS; ALANINE aminotransferase; LIVER; ANTHROPOMETRY; CONFIDENCE intervals; DIETARY supplements
- Publication
Nutrients, 2024, Vol 16, Issue 9, p1300
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16091300