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- Title
Urinary Neutrophil Gelatinase-Associated Lipocalin in Hepatorenal Syndrome: Population Diverdity Does it Matter Or Not?
- Authors
El-Makarem, Mona A. Abu; Mahmoud, Yehia Z.; El-Saghir, Shereen M.; Keryakos, Hesham K. Habeeb
- Abstract
Background: Hepatorenal syndrome (HRS) is a functional and potentially reversible form of AKI that occurs in cirrhosis patients with as cites caused by splanchnic vasodilatation, cardiovascular dysfunction and renal hypo-perfusion; all these hemodynamic changes are triggered by portal hypertension. SCr the clinical standard to define kidney function, poorly discriminates AKI type in cirrhosis so there is urgent need for new biomarkers for early detection and differential diagnosis of AKI in cirrhosis. This study was conducted in the Department of Internal Medicine, Minia University Hospital along the period from January and November . The aim of our study was validate the accuracy of urinary neutrophil gelatinase associated lipocalin (NGAL) in the diagnosis of HRS in Egyptian patients with hepatitis C virus (HCV) - related liver cirrhosis with serum creatinine as a gold standard test for kidney injury. Method: The study was conducted in the period from January 2015 and November 2015 on a group of patients with HCV-associated liver cirrhosis complicated with HRS Results: NGAL level was compared in group III versus group I we found that group III had higher level of NGAL (Mean ± SD of 732.9 ± 304.78 pg/ml vs. 40.07 ± 14.61 pg/ml, p < 0.001) and when it was compared between group III and group II we found that group III had higher level(Mean ± SD of 732.9 ± 304.78 pg/ ml vs. 62.6 ± 29.65 pg/ml, p < 0.001) Conclusions: • Urinary NGAL is valid biomarker for detection of AKI in hospitalized cirrhotic patients with AKI. • The studied urinary biomarker were positively correlated with liver specific scores indicating severity of liver disease and with ICU specific scores indicating multi-organ failure.
- Subjects
HEPATORENAL syndrome; LIPOCALIN-2; HEPATITIS C virus; CIRRHOSIS of the liver; LIVER diseases
- Publication
Indian Journal of Public Health Research & Development, 2020, Vol 11, Issue 5, p715
- ISSN
0976-0245
- Publication type
Article