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- Title
Liquid Nanosize Emulsion-Filled Enteric-Coated Capsules for Colon Delivery of Immunosuppressant Peptide.
- Authors
Sharma, Sumit; Sinha, Vivek Ranjan
- Abstract
Present study aims at solubilizing slightly water-soluble peptide into a nanosize emulsion which is filled into a hard gelatin capsule in the form of preconcentrate. Further, liquid-filled capsule was dip-coated with ethyl cellulose and Eudragit S100 for colon targeting. An <italic>in vitro</italic> release profile was studied for selected formulations, <italic>i.e.</italic>, Formulation A (5 mg ethyl cellulose and 40 mg Eudragit S100), Formulation B (10 mg ethyl cellulose and 30 mg Eudragit S100), and Formulation C (10 mg ethyl cellulose and 20 mg Eudragit S100). Formulations B and A showed an immediate release after 5 and 6 h, respectively, which represents ileo-ceacal transit time. The nanosize of emulsion, <italic>i.e.</italic>, below 100 nm, was confirmed by transmission electron microscopy. Also, a phase transition of nanosize emulsion from water in oil to oil in water on dilution with water was observed through TEM. This novel approach of filling poorly water-soluble protein in solubilized form of nanosize emulsion preconcentrate into coated hard gelatin capsules for colon targeting has been reported first time. This approach could be a breakthrough for the better management of local intestinal pathologies.
- Publication
AAPS PharmSciTech, 2018, Vol 19, Issue 2, p881
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-017-0886-y