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- Title
Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases.
- Authors
Yaw Kuang Chuah; Basir, Rusliza; Talib, Herni; Tung Hing Tie; Nordin, Norshariza
- Abstract
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized. In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions.
- Subjects
ALZHEIMER'S disease; ARTERIOSCLEROSIS; ARTHRITIS; CELL receptors; HYPERGLYCEMIA; INFLAMMATION; ADULT respiratory distress syndrome; SEPSIS
- Publication
International Journal of Inflammation, 2013, p1
- ISSN
2090-8040
- Publication type
Article
- DOI
10.1155/2013/403460