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- Title
Novel Adenovirus Vectors 'Capsid-Displaying' a Human Complement Inhibitor.
- Authors
Seregin, Sergey S.; Hartman, Zachary C.; Appledorn, Daniel M.; Godbehere, Sarah; Jiang, Haixiang; Frank, Michael M.; Amalfitano, Andrea
- Abstract
Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the full potential for Ad-based gene transfer applications. Therefore, we have constructed several novel Ad5-based vectors, 'capsid-displaying' as fiber or pIX fusion proteins, a complement-regulatory peptide (COMPinh). These novel Ads dramatically minimize Ad-dependent activation of the human and non-human primate complement systems, as determined by several assays. In summary, our work has shown that a novel COMPinh-displaying Ad5 has the potential for broadening the safe use of Ad vectors in future human applications. Copyright © 2010 S. Karger AG, Basel
- Publication
Journal of Innate Immunity, 2010, Vol 2, Issue 4, p353
- ISSN
1662-811X
- Publication type
Article
- DOI
10.1159/000284368