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- Title
Efficacy of a photo-catalyst towards the degradation of a pharmaceutical compound, 4-aminopyridine by application of response surface methodology.
- Authors
Chakraborty, Sucharita; Dutta, Suvanka; Saha, Rajnarayan; Moi, Sankar Chandra; Suku, Dipankar; Panja, Sujit Sankar
- Abstract
The present study demonstrates an intensive experimental study on the photo-degradation of pharmaceutical compound (4-Aminopyridine) in batch photo reactor with low energy ultraviolet light (125 nm) and using zinc oxide as catalyst. 4-Aminopyridine (4-AP) has been used for many years, prescribed for people with multiple sclerosis. This study aims to analyze the influence of operating parameters and their interactive effect on the overall removal efficiency of the targeted component in water by response surface methodology (RSM). Time (A, min), catalyst (B, gm/l), H2O2 (C, mg), and pH (D) were chosen as independent variables to optimize the percent removal of 4-Aminopyridine as response. The highest COD removal 97% was obtained at pH (5.3), ZnO (0.3 gm/l), H2O2 (3757 mg) within 49 min treatment time. Model predicted values were found in good agreement with the experimental values, and the behavior of the model equation has supported the experimental observation with minor deviation. Furthermore, the degradation of 4-AP was confirmed by the UV-V is spectrophotometer which showed continuous degradation after every 10 min time interval within an hour study and the FTIR (Fourier transform Infrared) spectrophotometer analysis reveals the modification of the functional groups present in the target compound after photo-catalytic treatment.
- Subjects
RESPONSE surfaces (Statistics); ZINC catalysts; ULTRAVIOLET radiation; BATCH reactors; FOURIER transforms
- Publication
Desalination & Water Treatment, 2017, Vol 76, p389
- ISSN
1944-3994
- Publication type
Article
- DOI
10.5004/dwt.2017.20580