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- Title
Bioactive quinone derivatives from the marine brown alga Sargassum thunbergii induce anti-adipogenic and pro-osteoblastogenic activities.
- Authors
Kim, Jung‐Ae; Karadeniz, Fatih; Ahn, Byul‐Nim; Kwon, Myeong Sook; Mun, Ok‐Ju; Bae, Min Joo; Seo, Youngwan; Kim, Mihyang; Lee, Sang‐Hyeon; Kim, Yuck Yong; Mi‐Soon, Jang; Kong, Chang‐Suk
- Abstract
BACKGROUND Health problems related to the lack of bone formation are a major problem for ageing populations in the modern world. As a part of the ongoing trend to develop natural substances that attenuate bone loss in osteoporosis, the effects of the edible brown alga Sargassum thunbergii and its active contents on adipogenic differentiation in 3T3-L1 fibroblasts and osteoblast differentiation in MC3T3-E1 pre-osteoblasts were evaluated. RESULTS Treatment with S. thunbergii significantly reduced lipid accumulation and expression of adipogenic differentiation markers such as peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein α and sterol regulatory element binding protein 1c. In addition, S. thunbergii successfully enhanced osteoblast differentiation as indicated by increased alkaline phosphatase activity along raised levels of osteoblastogenesis indicators, namely bone morphogenetic protein-2, osteocalcin and collagen type I. Two compounds, sargaquinoic and sargahydroquinoic acid, were isolated from active extract and shown to be active by means of osteogenesis inducement. CONCLUSION S. thunbergii could be a source for functional food ingredients for improved treatment of osteoporosis and obesity. © 2015 Society of Chemical Industry
- Subjects
BIOACTIVE compounds; QUINONE derivatives; MARINE algae; SARGASSUM; OSTEOPOROSIS treatment; ADIPOGENESIS; OSTEOBLASTS
- Publication
Journal of the Science of Food & Agriculture, 2016, Vol 96, Issue 3, p783
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.7148