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- Title
Indolent course of cutaneous gamma-delta T-cell lymphoma.
- Authors
Endly, Dawnielle C.; Weenig, Roger H.; Peters, Margot S.; Viswanatha, David S.; Comfere, Nneka I.
- Abstract
Cutaneous gamma-delta T-cell lymphoma (γδ TCL) is a rare malignancy that typically displays an aggressive clinical course. We present an unusual case of a 57-year-old woman with a 3-year history of lower extremity nodules. Histopathologic, immunophenotypic and molecular genetic studies revealed a clonal, predominantly pannicular gamma-delta T-cell infiltrate, leading to a diagnosis of cutaneous γδ TCL. The clinical course was characterized by rapid improvement within months of starting systemic corticosteroids, with relapse in ulcerations but no new lesions more than 3 years after onset of disease. Our case and seven previously reported patients with indolent and relatively localized cutaneous γδ TCL provide evidence that not all cases of this entity carry a poor prognosis. This indolent subset adds complexity to treatment of cutaneous γδ TCL.
- Subjects
T-cell lymphoma; LYMPHOMAS; ADRENOCORTICAL hormones; HORMONE therapy; CONNECTIVE tissue diseases; LEG; TUMORS
- Publication
Journal of Cutaneous Pathology, 2013, Vol 40, Issue 10, p896
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.12091