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- Title
Disfunción endotelial evaluada a través de fotopletismografía en pacientes con diabetes mellitus tipo 2.
- Authors
Castillo-Martínez, L.; Ortiz-Suárez, G.; Montañez-Orozco, A.; Orea-Tejeda, A.; Keirns-Davis, C.; Dávila-Radilla, F.; Alcalá-Dávila, E.; Kauffman-Ortega, E.; Infante-Vázquez, O.; Martínez Memije, R.
- Abstract
BACKGROUND: Diabetes mellitus (DM) reduces life expectancy by a third, principally because of cardiovascular disease and endothelial dysfunction are considered the first manifestations of vascular disease. Photoplethysmography is a non-invasive technique to evaluate endothelial dysfunction based on the emission of infra-red light on the skin. OBJECTIVE: To evaluate endothelial function by photoplethysmography in patients with type 2 DM without evidence of vascular disease. MATERIAL AND METHOD: A cross-sectional study of patients with and without DM was undertaken. Endothelial function was evaluated using photoplethysmographic waves taking into consideration the shape of the curve and time of maximum amplitude/total time of the curve (TMA/TT) before and after ischemia induced by arterial obstruction. RESULTS: In 174 subjects included, a greater basal TMA/TT index was found in diabetics, even after adjusting for age, hypertension, dyslipidemia and hypothyroidism. The percentage of change in amplitude post-ischemia compared to basal value was diminished in diabetics (p=0.030). Persons with diabetes, with and without endothelial dysfunction, had comparable HbA1c concentrations; but diabetics with endothelial dysfunction had lower serum concentration of HDL-C (p=0.05). CONCLUSIONS: More endothelial dysfunction was found in patients with diabetes. While the control of diabetes did not influence endothelial dysfunction, it was associated with lower HDL cholesterol.
- Publication
Medicina Interna de Mexico, 2016, Vol 32, Issue 3, p296
- ISSN
0186-4866
- Publication type
Article