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- Title
Syntheses and Reactions of 4'-[(ω-Bromoalkyl)oxy]-and 4',4'"-(Polymethylenedoxy)-bis Substituted Chalcones.
- Authors
Sodani, R. S.; Choudhary, Prakash C.; Sharma, Hari Om; Verma, B. L.
- Abstract
Base catalyzed condensation of 4-hydroxyacetophenone (1) with several aldehydes resulted 4'-hydroxychalcones (2a-c). Reaction of α,ω- dibromoalkanes (3, n=2, 4 & 6) with (2a-c) in equimolar ratio resulted a mixture of 4'-[(w-bromoalkyl)oxy]- substituted chalcones (4a-i) and 4',4'''- (polymethylenedioxy)-bis substituted chalcones (5a-i) separated by ethanol as soluble (4a-i) and insoluble (5a-i) products. Compounds (5a-i) were also synthesized by another route. Compound 1 on treatment with 3 in molar ratio 2:1 resulted 4',4'''-(polymethylenedioxy)-diacetophenone (4#a-c) which on base catalyzed condensation gave compounds (5a-i). Reaction of 4d with substituted phenols and thiophenols gave corresponding phenoxy and thiophenoxy substituted chalcones (6a-f) where as compounds 5a, 5b, 5d, 5h and 5e on treatment with hydrazine hydrate furnished corresponding bis-2- pyrazolines (7a-e). The structures of all synthesized compounds were confirmed on the basis of analytical and spectral data.
- Subjects
CATALYSIS; CONDENSATION; ALDEHYDES; ANTIMALARIALS; PARAFFIN wax; SPECTRUM analysis; HYDRAZINES; CARBON compounds; AROMATIC compounds
- Publication
E-Journal of Chemistry, 2010, Vol 7, Issue 3, p763
- ISSN
0973-4945
- Publication type
Article
- DOI
10.1155/2010/807059