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- Title
Cardio-Pulmonary Histopathology with Clinical Correlations of Deceased Patients with COVID-19: A Case Series in Tehran, Iran.
- Authors
Soleiman-Meigooni, Saeed; Yaghmayee, Ramin; Mohammadi, Shadi; Ahmadi, Mousa; Sakhabakhsh, Mehdi; Hamidi-Farahani, Ramin; Hazrati, Ebrahim; Jazayeri, Seyed Mohammad; Fotoohi, Mahtab; Motemaveleh, Akram; Doulatabadi-Farahani, Vahid; Shahmohamadi, Farhad; Kazemi-Galougahi, Mohammad Hassan; Asgari, Ali; Aminianfar, Mohammad; Darvishi, Mohammad; Mohajeri-Iravani, Mojgan; Gholizadeh, Omid
- Abstract
Background: SARS-CoV-2 may affect vital organs. The present study investigated the histopathology of pulmonary and cardiac tissues with clinical correlation in deceased patients with COVID-19. Methods: We obtained pulmonary and cardiac tissues from 30 deceased patients with COVID-19 in Tehran, Iran, from January to May 2021. Sampling was performed through a percutaneous needle biopsy. After slide preparation, two expert pathologists studied them. We assessed the correlation between clinical and pathological data by Fisher's exact test. Results: The mean age of the patients was 73.8 ± 13.4 years, and the male-to-female ratio was 23/7. The most common underlying disease was hypertension (HTN) in 25 patients (83%). Fifty-five tissue samples were achieved, including 28 pulmonary and 27 cardiac samples. Our results showed that all patients (100%) developed diffuse alveolar damage (DAD), and 26 (93%) developed hyaline membrane formation. The most common phase of DAD was the exudative-proliferative phase in 16 (57.1%). Three cardiac samples (11%) revealed myocarditis, and seven (26%) showed cardiomyocyte hypertrophy. In univariate analysis using Fischer's exact test, myocarditis had significant relationships with C-reactive protein (CRP) levels higher than 80 mg/dL (P = 0.008) and elevated cardiac troponin levels higher than two-fold (P = 0.01). Conclusion: COVID-19 can affect the major vital organs. However, only myocarditis had a significant relationship with the circulating levels of inflammatory factors.
- Subjects
IRAN; MEDICAL cadavers; RESEARCH; PULMONARY alveoli; STATISTICS; C-reactive protein; TROPONIN; COVID-19; HYALINE membrane disease; MYOCARDIUM; HEART cells; LUNGS; HEART; AUTOPSY; CARDIOMYOPATHIES; CARDIAC hypertrophy; FISHER exact test; TISSUES; HISTOLOGICAL techniques; CASE studies; RESEARCH funding; DESCRIPTIVE statistics; STATISTICAL correlation; NEEDLE biopsy
- Publication
Archives of Iranian Medicine (AIM), 2023, Vol 26, Issue 5, p252
- ISSN
1029-2977
- Publication type
Article
- DOI
10.34172/aim.2023.39