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- Title
Effect of N-acetylcysteine on inflammation biomarkers in pediatric acute pyelonephritis: a randomized controlled trial.
- Authors
Allameh, Zahra; Karimi, Abdollah; Tabatabaei, Seddigheh Rafiei; Sharifian, Mostafa; Salamzadeh, Jamshid; Rafiei Tabatabaei, Seddigheh
- Abstract
<bold>Introduction: </bold>This study was designed to investigate the effect of N-acetylcysteine (NAC), as a potent and safe antioxidant, on inflammatory biomarkers of acute pyelonephritis in pediatric patients.<bold>Materials and Methods: </bold>Children (< 15 years old) admitted with a diagnosis of pyelonephritis were recruited in a randomized placebo-controlled trial. They were randomly allocated to 2 groups and recieved placebo or NAC effervescent tablets with daily dose based on their weight, for 5 days. The children were evaluated for serum procalcitonin level, leukocyte count, C-reactive protein (CRP), serum creatinine, and clinical symptoms on the 1st and the 5th days.<bold>Results: </bold>Seventy patients, 35 in each group, with a mean age of 5.54 ± 3.10 years completed the study. There was no significant difference between the two groups in the amount of changes in procalcitonin levels after 5 days (P = .90). Within-group analysis confirmed CRP reduction in both groups (P < .001); however, between-group analysis did not show significant difference in CRP reductions, either (P = .65). No significant differences were found between the two groups in the day of resolving pyuria (P = .46), day of resolving bacteriuria (P = .81), or reductions in leukocyte count (P = .64) and neutrophil count (P = .49).<bold>Conclusions: </bold>A short period of NAC administration with the recommended doses could not lead to a significant decrease in inflammation biomarkers. Studies on higher doses and longer duration of NAC administration along with evaluation of the long-term effects of the intervention by tools such as renal scntigraphy are suggested.
- Subjects
ACETYLCYSTEINE; PYELONEPHRITIS treatment; LEUKOCYTE count; C-reactive protein; CREATININE; FREE radical scavengers; CALCITONIN; COMPARATIVE studies; INFLAMMATION; RESEARCH methodology; MEDICAL cooperation; PROTEIN precursors; PYELONEPHRITIS; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment; ACUTE diseases; DISEASE complications; THERAPEUTICS
- Publication
Iranian Journal of Kidney Diseases, 2015, Vol 9, Issue 6, p454
- ISSN
1735-8582
- Publication type
journal article