We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High-dose unfractionated heparin therapy in a pregnant patient with antiphospolipid syndrome: a case report.
- Authors
Hiroshi Ogishima; Satoshi Ito; Akito Tsutsumi; Makoto Sugihara; Daisuke Goto; Isao Matsumoto; Mana Obata-yasuoka; Hiromi Hamada; Hiroyuki Yoshikawa; Hideto Takahashi; Atsuko Murashima; Takayuki Sumida
- Abstract
A case of a 37-year-old pregnant patient with antiphospholipid syndrome (APS), who has a medical history of both thrombosis and recurrent fetal loss, is presented. She was treated with predonisolone and fixed-dose unfractionated heparin (UFH) infusion, followed by plasmaphereses and fixed-dose low-molecular-weight heparin infusion during her fourth pregnancy. Unfortunately, this treatment did not have beneficial effects, resulting in intrauterine growth restriction and finally neonatal death. Continuous intravenous UFH infusion and low-dose aspirin were administrated under the monitoring of the activated partial thromboplastin time to achieve a target level of 120 s during her fifth pregnancy. A healthy baby weighing 1818 g at birth was delivered by Cesarean section at the 34th week of pregnancy. High-dose UFH infusion may be considered to be one of the preferable options to manage pregnant patients with refractory APS.
- Subjects
CASE studies; PREGNANCY complications; HEPARIN; THROMBOSIS; PREGNANT women; NEONATAL death; ASPIRIN; CESAREAN section
- Publication
International Journal of Rheumatic Diseases, 2010, Vol 13, Issue 3, pe32
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/j.1756-185X.2010.01484.x