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- Title
Portal Vein Thrombosis After Hepatectomy.
- Authors
Yoshiya, Shohei; Shirabe, Ken; Nakagawara, Hidekazu; Soejima, Yuji; Yoshizumi, Tomoharu; Ikegami, Toru; Yamashita, Yo-ichi; Harimoto, Norifumi; Nishie, Akihiro; Yamanaka, Takeharu; Maehara, Yoshihiko
- Abstract
Background: Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. Methods: The preoperative and postoperative clinical characteristics of patients who underwent hepatectomy were retrospectively analyzed. Results: A total of 208 patients were reviewed. The incidence of PVT after hepatectomy was 9.1 % ( n = 19), including main portal vein (MPV) thrombosis ( n = 7) and peripheral portal vein (PPV) thrombosis ( n = 12). Patients with MPV thrombosis had a significantly higher incidence of right hepatectomy ( p < 0.001), larger resection volume ( p = 0.003), and longer operation time ( p = 0.021) than patients without PVT ( n = 189). Multivariate analysis identified right hepatectomy as a significant independent risk factor for MPV thrombosis (odds ratio 108.9; p < 0.001). Patients with PPV thrombosis had a significantly longer duration of Pringle maneuver than patients without PVT ( p = 0.002). Among patients who underwent right hepatectomy, those with PVT ( n = 6) had a significantly lower early liver regeneration rate than those without PVT ( n = 13; p = 0.040), and those with PVT had deterioration of liver function on postoperative day 7. In all patients with MPV thrombosis who received anticoagulation therapy, PVT subsequently resolved. Conclusions: Postoperative PVT after hepatectomy is not rare. It is closely related to delayed recovery of liver function and delayed liver regeneration.
- Subjects
SURGERY; SURGICAL complications; HEPATECTOMY; PORTAL vein diseases; THROMBOSIS risk factors
- Publication
World Journal of Surgery, 2014, Vol 38, Issue 6, p1491
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-013-2440-8