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- Title
Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.
- Authors
Whitworth, Caroline E.; Fleming, Stewart; Cumming, Allan D.; Morton, James J.; Burns, Nicola J. T.; Williams, Brent C.; Mullins, John J.
- Abstract
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation, it appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
- Subjects
HYPERTENSION; BLOOD circulation disorders; BLOOD pressure; CHRONIC kidney failure; LABORATORY rats
- Publication
Kidney International, 1994, Vol 46, Issue 6, p1528
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1994.437