We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biocomposite scaffolds for 3D cell culture: Propolis enriched polyvinyl alcohol nanofibers favoring cell adhesion.
- Authors
Bilginer, Rumeysa; Ozkendir‐Inanc, Dilce; Yildiz, Umit Hakan; Arslan‐Yildiz, Ahu
- Abstract
The objective of this work is generation of propolis/polyvinyl alcohol (PVA) scaffold by electrospinning for 3D cell culture. Here, PVA used as co‐spinning agent since propolis alone cannot be easily processed by electrospinning methodology. Propolis takes charge in maximizing biological aspect of scaffold to facilitate cell attachment and proliferation. Morphological analysis showed size of the electrospun nanofibers varied between 172–523 nm and 345–687 nm in diameter, for non‐crosslinked and crosslinked scaffolds, respectively. Incorporation of propolis resulted in desired surface properties of hybrid matrix, where hybrid scaffolds highly favored protein adsorption. To examine cell compatibility, NIH‐3T3 and HeLa cells were seeded on propolis/PVA hybrid scaffold. Results confirmed that integration of propolis supported cell adhesion and cell proliferation. Also, results indicated electrospun propolis/PVA hybrid scaffold provide suitable microenvironment for cell culturing. Therefore, developed hybrid scaffold could be considered as potential candidate for 3D cell culture and tissue engineering.
- Subjects
PROPOLIS; POLYVINYL alcohol; CELL culture; CELL adhesion; TISSUE scaffolds; TISSUE culture; NANOFIBERS
- Publication
Journal of Applied Polymer Science, 2021, Vol 138, Issue 17, p1
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.50287