We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of proinflammatory cytokines in cisplatin-induced vestibular hair cell damage.
- Authors
Hyung-Jin Kim; Hong-Seob So; Jeong-Han Lee; Channy Park; Jin-Bin Lee; Myung-Ja Youn; Se-Jin Kim; Sei-Hoon Yang; Kang-Min Lee; Kang-Beom Kwon; Byung-Hyun Park; Raekil Park
- Abstract
Background. Cisplatin causes the impairment of inner ear functions, including hearing and balance, through the involvement of a number of mechanisms. However, no laboratory studies have been performed on involvement of inflammation-related events in cisplatin-mediated vestibular dysfunction. Methods. We evaluated the secretion of proinflammatory cytokines and nuclear factor-κB (NF-κB) activation in cisplatin-treated UB/UE-1 utricular epithelial cells. We also employed immunohistochemistry to detect proinflammatory cytokines and NF-κB expression in cisplatin-injected mice. Results. Productions of proinflammatory cytokines significantly caused the death of UB/UE1 cells by cisplatin. Pharmacologic inhibition of mitogen-activated protein (MAP) kinase/ERK kinase-1 (MEK1) or extracellular signal-regulated kinase (ERK) significantly attenuated the death of UB/UE1 cells caused by cisplatin and proinflammatory cytokines. Immunohistochemical studies revealed an increase in the expression of proinflammatory cytokines and NF-κB in both the cristae ampullae and utricle of cisplatin-injected mice. Conclusions. These results suggest that proinflammatory cytokines may play an important role in the pathogenesis of cisplatin-mediated vestibulotoxicity. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
- Subjects
CISPLATIN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY of inflammation; CYTOKINES; ANTINEOPLASTIC agents; EXFOLIATIVE cytology
- Publication
Head & Neck, 2008, Vol 30, Issue 11, p1445
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.20892