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- Title
Fc γ receptor polymorphisms and their association with periodontal disease: a meta-analysis.
- Authors
Dimou, Niki L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G.
- Abstract
Dimou NL, Nikolopoulos GK, Hamodrakas SJ, Bagos PG. Fc γ receptor polymorphisms and their association with periodontal disease: a meta-analysis. J Clin Periodontol 2010. 37: 255–265 doi: 10.1111/j.1600-051X.2009.01530.x. Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fc γ receptor (Fc γR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials and Methods: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: Fc γRIIA H131R (rs1801274), Fc γRIIIA F158V (rs396991) and Fc γRIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. Results and Conclusions: The Fc γRIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the Fc γRIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between Fc γRIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between Fc γRIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene–gene or gene–environment interactions (i.e. with smoking).
- Subjects
PERIODONTAL disease; META-analysis; GENETIC polymorphisms; CONFIDENCE intervals; PERIODONTITIS
- Publication
Journal of Clinical Periodontology, 2010, Vol 37, Issue 3, p255
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/j.1600-051X.2009.01530.x