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- Title
Cardiorespiratory physiology in the safe passage study: protocol, methods and normative values in unexposed infants.
- Authors
Myers, Michael M.; Elliott, Amy J.; Odendaal, Hein J.; Burd, Larry; Angal, Jyoti; Groenewald, Coen; Nugent, James David; Yang, Joel S.; Isler, Joseph R.; Dukes, Kim A.; Robinson, Fay; Fifer, William P.; Sullivan, Lisa M.; Tripp, Tara; Petersen, Julie M.; Young, Rebecca A.; Baker, Travis; Petersen, Derek; Toland, Gregory; Kinney, Hannah C.
- Abstract
<bold>Aim: </bold>The Safe Passage Study, conducted by the Prenatal Alcohol in SIDS and Stillbirth Network, is investigating contributions of prenatal alcohol exposure to foetal and infant demise. This current report presents physiological data from full-term infants with no prenatal exposure to alcohol or maternal smoking.<bold>Methods: </bold>Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head-up tilts shortly after birth and at one month of age.<bold>Results: </bold>Analyses revealed significant increases in heart rate and decreases in BP from the newborn to one-month time period as well as diminished heart rate responses to head-up tilt in one-month-old infants.<bold>Conclusion: </bold>The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for SIDS. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for SIDS.
- Subjects
INFANT death; SUDDEN infant death syndrome; ALCOHOLISM in pregnancy; WOMEN'S tobacco use; PREGNANT women; CARDIOPULMONARY system physiology; FETAL alcohol syndrome; AGE distribution; COMPARATIVE studies; NEWBORN infants; NEWBORN screening; RESEARCH methodology; MEDICAL cooperation; REFERENCE values; RESEARCH; RESEARCH funding; SLEEP; VITAL signs; EVALUATION research
- Publication
Acta Paediatrica, 2017, Vol 106, Issue 8, p1260
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.13873