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Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation.
Published in:
2018
By:
- Changshan Wang;
- Motohiko Oshima;
- Daisuke Sato;
- Hirotaka Matsui;
- Sho Kubota;
- Kazumasa Aoyama;
- Yaeko Nakajima-Takagi;
- Shuhei Koide;
- Jun Matsubayashi;
- Makiko Mochizuki-Kashio;
- Takako Nakano-Yokomizo;
- Jie Bai;
- Toshitaka Nagao;
- Akinori Kanai;
- Goro Sashida;
- Wang, Changshan;
- Oshima, Motohiko;
- Sato, Daisuke;
- Matsui, Hirotaka;
- Kubota, Sho
Publication type:
journal article
iPSC-derived megakaryocytes and platelets accelerate wound healing and angiogenesis.
Published in:
Stem Cell Research & Therapy, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13287-024-03966-z
By:
- Kosaka, Kentaro;
- Takayama, Naoya;
- Paul, Sudip Kumar;
- Kanashiro, Maria Alejandra;
- Oshima, Motohiko;
- Fukuyo, Masaki;
- Rahmutulla, Bahityar;
- Tajiri, Ikuko;
- Mukai, Michiaki;
- Kubota, Yoshitaka;
- Akita, Shinsuke;
- Furuyama, Nobutaka;
- Kaneda, Atsushi;
- Iwama, Atsushi;
- Eto, Koji;
- Mitsukawa, Nobuyuki
Publication type:
Article
The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms.
Published in:
Cancer Immunology, Immunotherapy, 2023, v. 72, n. 8, p. 2635, doi. 10.1007/s00262-023-03447-x
By:
- Shibamiya, Asuka;
- Miyamoto-Nagai, Yurie;
- Koide, Shuhei;
- Oshima, Motohiko;
- Rizq, Ola;
- Aoyama, Kazumasa;
- Nakajima-Takagi, Yaeko;
- Kato, Rei;
- Kayamori, Kensuke;
- Isshiki, Yusuke;
- Oshima-Hasegawa, Nagisa;
- Muto, Tomoya;
- Tsukamoto, Shokichi;
- Takeda, Yusuke;
- Koyama-Nasu, Ryo;
- Chiba, Tetsuhiro;
- Honda, Hiroaki;
- Yokote, Koutaro;
- Iwama, Atsushi;
- Sakaida, Emiko
Publication type:
Article
Forkhead box protein A1 confers resistance to transforming growth factor‐β‐induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
Published in:
Journal of Cellular Biochemistry, 2019, v. 120, n. 2, p. 2259, doi. 10.1002/jcb.27551
By:
- Hirata, Kensuke;
- Takakura, Yuki;
- Shibazaki, Misato;
- Morii, Mariko;
- Honda, Takuya;
- Oshima, Motohiko;
- Aoyama, Kazumasa;
- Iwama, Atsushi;
- Nakayama, Yuji;
- Takano, Hiroyuki;
- Yamaguchi, Naoto;
- Yamaguchi, Noritaka
Publication type:
Article
Forkhead box protein A1 confers resistance to transforming growth factor‐β‐induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
Published in:
Journal of Cellular Biochemistry, 2019, v. 120, n. 2, p. 2259, doi. 10.1002/jcb.27551
By:
- Hirata, Kensuke;
- Takakura, Yuki;
- Shibazaki, Misato;
- Morii, Mariko;
- Honda, Takuya;
- Oshima, Motohiko;
- Aoyama, Kazumasa;
- Iwama, Atsushi;
- Nakayama, Yuji;
- Takano, Hiroyuki;
- Yamaguchi, Naoto;
- Yamaguchi, Noritaka
Publication type:
Article
A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo.
Published in:
Inflammation & Regeneration, 2023, v. 43, n. 1, p. 1, doi. 10.1186/s41232-023-00292-4
By:
- Melig, Gerel;
- Nobuhisa, Ikuo;
- Saito, Kiyoka;
- Tsukahara, Ryota;
- Itabashi, Ayumi;
- Kanai, Yoshiakira;
- Kanai-Azuma, Masami;
- Osawa, Mitsujiro;
- Oshima, Motohiko;
- Iwama, Atsushi;
- Taga, Tetsuya
Publication type:
Article
Cooperative impact of Utx loss and Braf V600E mutation induces myeloma in mice.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2019, v. 19, p. e20, doi. 10.1016/j.clml.2019.09.030
By:
- Rizq, Ola;
- Mimura, Naoya;
- Oshima, Motohiko;
- Momose, Shuji;
- Nakajima-Takagi, Yaeko;
- Aoyama, Kazumasa;
- Saraya, Atsunori;
- Iseki, Tohru;
- Sakaida, Emiko;
- Nakaseko, Chiaki;
- Okuno, Yutaka;
- Honda, Hiroaki;
- Tamaru, Jun-ichi;
- Tai, Yu-Tzu;
- Anderson, Kenneth C.;
- Iwama, Atsushi
Publication type:
Article
Epigenetic Memories in Hematopoietic Stem and Progenitor Cells.
Published in:
Cells (2073-4409), 2022, v. 11, n. 14, p. N.PAG, doi. 10.3390/cells11142187
By:
- Aoyama, Kazumasa;
- Itokawa, Naoki;
- Oshima, Motohiko;
- Iwama, Atsushi
Publication type:
Article
Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30440-2
By:
- Itokawa, Naoki;
- Oshima, Motohiko;
- Koide, Shuhei;
- Takayama, Naoya;
- Kuribayashi, Wakako;
- Nakajima-Takagi, Yaeko;
- Aoyama, Kazumasa;
- Yamazaki, Satoshi;
- Yamaguchi, Kiyoshi;
- Furukawa, Yoichi;
- Eto, Koji;
- Iwama, Atsushi
Publication type:
Article
Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells.
Published in:
Stem Cells International, 2019, p. 1, doi. 10.1155/2019/9789240
By:
- Kanayama, Kengo;
- Chiba, Tetsuhiro;
- Oshima, Motohiko;
- Kanzaki, Hiroaki;
- Koide, Shuhei;
- Saraya, Atsunori;
- Miyagi, Satoru;
- Mimura, Naoya;
- Kusakabe, Yuko;
- Saito, Tomoko;
- Ogasawara, Sadahisa;
- Suzuki, Eiichiro;
- Ooka, Yoshihiko;
- Maruyama, Hitoshi;
- Iwama, Atsushi;
- Kato, Naoya
Publication type:
Article
Deregulated Polycomb functions in myeloproliferative neoplasms.
Published in:
2019
By:
- Sashida, Goro;
- Oshima, Motohiko;
- Iwama, Atsushi
Publication type:
journal article
Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26435-0
By:
- Kimishima, Yusuke;
- Misaka, Tomofumi;
- Yokokawa, Tetsuro;
- Wada, Kento;
- Ueda, Koki;
- Sugimoto, Koichi;
- Minakawa, Keiji;
- Nakazato, Kazuhiko;
- Ishida, Takafumi;
- Oshima, Motohiko;
- Koide, Shuhei;
- Shide, Kotaro;
- Shimoda, Kazuya;
- Iwama, Atsushi;
- Ikeda, Kazuhiko;
- Takeishi, Yasuchika
Publication type:
Article
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.
Published in:
Nature Communications, 2014, v. 5, n. 6, p. 4177, doi. 10.1038/ncomms5177
By:
- Sashida, Goro;
- Harada, Hironori;
- Matsui, Hirotaka;
- Oshima, Motohiko;
- Yui, Makiko;
- Harada, Yuka;
- Tanaka, Satomi;
- Mochizuki-Kashio, Makiko;
- Wang, Changshan;
- Saraya, Atsunori;
- Muto, Tomoya;
- Hayashi, Yoshihiro;
- Suzuki, Kotaro;
- Nakajima, Hiroshi;
- Inaba, Toshiya;
- Koseki, Haruhiko;
- Huang, Gang;
- Kitamura, Toshio;
- Iwama, Atsushi
Publication type:
Article
Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0084807
By:
- Chiba, Tetsuhiro;
- Suzuki, Eiichiro;
- Yuki, Kaori;
- Zen, Yoh;
- Oshima, Motohiko;
- Miyagi, Satoru;
- Saraya, Atsunori;
- Koide, Shuhei;
- Motoyama, Tenyu;
- Ogasawara, Sadahisa;
- Ooka, Yoshihiko;
- Tawada, Akinobu;
- Nakatsura, Tetsuya;
- Hayashi, Takehiro;
- Yamashita, Taro;
- Kaneko, Syuichi;
- Miyazaki, Masaru;
- Iwama, Atsushi;
- Yokosuka, Osamu
Publication type:
Article
Metformin, a Diabetes Drug, Eliminates Tumor-Initiating Hepatocellular Carcinoma Cells.
Published in:
PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0070010
By:
- Saito, Tomoko;
- Chiba, Tetsuhiro;
- Yuki, Kaori;
- Zen, Yoh;
- Oshima, Motohiko;
- Koide, Shuhei;
- Motoyama, Tenyu;
- Ogasawara, Sadahisa;
- Suzuki, Eiichiro;
- Ooka, Yoshihiko;
- Tawada, Akinobu;
- Tada, Motohisa;
- Kanai, Fumihiko;
- Takiguchi, Yuichi;
- Iwama, Atsushi;
- Yokosuka, Osamu
Publication type:
Article
Bmi1 Confers Resistance to Oxidative Stress on Hematopoietic Stem Cells.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036209
By:
- Nakamura, Shunsuke;
- Oshima, Motohiko;
- Jin Yuan;
- Saraya, Atsunori;
- Miyagi, Satoru;
- Konuma, Takaaki;
- Yamazaki, Satoshi;
- Osawa, Mitsujiro;
- Nakauchi, Hiromitsu;
- Koseki, Haruhiko;
- Iwama, Atsushi
Publication type:
Article
Epigenetics of hematopoietic stem cell aging and disease.
Published in:
International Journal of Hematology, 2014, v. 100, n. 4, p. 326, doi. 10.1007/s12185-014-1647-2
By:
- Oshima, Motohiko;
- Iwama, Atsushi
Publication type:
Article
Context- dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.87674
By:
- Shintaro Watanuki;
- Hiroshi Kobayashi;
- Yuki Sugiura;
- Masamichi Yamamoto;
- Daiki Karigane;
- Kohei Shiroshita;
- Yuriko Sorimach;
- Shinya Fujita;
- Takayuki Morikawa;
- Shuhei Koide;
- Motohiko Oshima;
- Akira Nishiyama;
- Koichi Murakami;
- Miho Haraguchi;
- Shinpei Tamaki;
- Takehiro Yamamoto;
- Tomohiro Yabushita;
- Yosuke Tanaka;
- Go Nagamatsu;
- Hiroaki Honda
Publication type:
Article
Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.83004
By:
- Yaeko Nakajima- Takagi;
- Motohiko Oshima;
- Junichiro Takano;
- Shuhei Koide;
- Naoki Itokawa;
- Shun Uemura;
- Masayuki Yamashita;
- Shohei Andoh;
- Atsushi Iwama
Publication type:
Article
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-00889-0
By:
- Kusakabe, Yuko;
- Chiba, Tetsuhiro;
- Oshima, Motohiko;
- Koide, Shuhei;
- Rizq, Ola;
- Aoyama, Kazumasa;
- Ao, Junjie;
- Kaneko, Tatsuya;
- Kanzaki, Hiroaki;
- Kanayama, Kengo;
- Maeda, Takahiro;
- Saito, Tomoko;
- Nakagawa, Ryo;
- Kobayashi, Kazufumi;
- Kiyono, Soichiro;
- Nakamura, Masato;
- Ogasawara, Sadahisa;
- Suzuki, Eiichiro;
- Nakamoto, Shingo;
- Yasui, Shin
Publication type:
Article
Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome.
Published in:
Cancer Science, 2020, v. 111, n. 12, p. 4336, doi. 10.1111/cas.14684
By:
- Zhong, Cheng;
- Kayamori, Kensuke;
- Koide, Shuhei;
- Shinoda, Daisuke;
- Oshima, Motohiko;
- Nakajima‐Takagi, Yaeko;
- Nagai, Yurie;
- Mimura, Naoya;
- Sakaida, Emiko;
- Yamazaki, Satoshi;
- Iwano, Satoshi;
- Miyawaki, Atsushi;
- Ito, Ryoji;
- Tohyama, Kaoru;
- Yamaguchi, Kiyoshi;
- Furukawa, Yoichi;
- Lennox, William;
- Sheedy, Josephine;
- Weetall, Marla;
- Iwama, Atsushi
Publication type:
Article
Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.
Published in:
Cancer Science, 2019, v. 110, n. 12, p. 3695, doi. 10.1111/cas.14207
By:
- Rizk, Mohamed;
- Rizq, Ola;
- Oshima, Motohiko;
- Nakajima‐Takagi, Yaeko;
- Koide, Shuhei;
- Saraya, Atsunori;
- Isshiki, Yusuke;
- Chiba, Tetsuhiro;
- Yamazaki, Satoshi;
- Ma, Anqi;
- Jin, Jian;
- Iwama, Atsushi;
- Mimura, Naoya
Publication type:
Article
Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48663-w
By:
- Paul, Sudip Kumar;
- Oshima, Motohiko;
- Patil, Ashwini;
- Sone, Masamitsu;
- Kato, Hisaya;
- Maezawa, Yoshiro;
- Kaneko, Hiyori;
- Fukuyo, Masaki;
- Rahmutulla, Bahityar;
- Ouchi, Yasuo;
- Tsujimura, Kyoko;
- Nakanishi, Mahito;
- Kaneda, Atsushi;
- Iwama, Atsushi;
- Yokote, Koutaro;
- Eto, Koji;
- Takayama, Naoya
Publication type:
Article
A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies.
Published in:
Molecular Neurobiology, 2018, v. 55, n. 7, p. 5993, doi. 10.1007/s12035-017-0815-9
By:
- Umehara, Kenta;
- Sun, Yuchen;
- Hiura, Satoshi;
- Hamada, Koki;
- Itoh, Motoyuki;
- Kitamura, Keita;
- Oshima, Motohiko;
- Iwama, Atsushi;
- Saito, Kosuke;
- Anzai, Naohiko;
- Chiba, Kan;
- Akita, Hidetaka;
- Furihata, Tomomi
Publication type:
Article
Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.
Published in:
2019
By:
- Kubota, Sho;
- Tokunaga, Kenji;
- Umezu, Tomohiro;
- Yokomizo-Nakano, Takako;
- Sun, Yuqi;
- Oshima, Motohiko;
- Tan, Kar Tong;
- Yang, Henry;
- Kanai, Akinori;
- Iwanaga, Eisaku;
- Asou, Norio;
- Maeda, Takahiro;
- Nakagata, Naomi;
- Iwama, Atsushi;
- Ohyashiki, Kazuma;
- Osato, Motomi;
- Sashida, Goro
Publication type:
Correction Notice
Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09710-z
By:
- Kubota, Sho;
- Tokunaga, Kenji;
- Umezu, Tomohiro;
- Yokomizo-Nakano, Takako;
- Sun, Yuqi;
- Oshima, Motohiko;
- Tan, Kar Ton;
- Yang, Henry;
- Kanai, Akinori;
- Iwanaga, Eisaku;
- Asou, Norio;
- Maeda, Takahiro;
- Nakagata, Naomi;
- Iwama, Atsushi;
- Ohyashiki, Kazuma;
- Osato, Motomi;
- Sashida, Goro
Publication type:
Article
Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.
Published in:
PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0154561
By:
- Si, Sha;
- Nakajima-Takagi, Yaeko;
- Aoyama, Kazumasa;
- Oshima, Motohiko;
- Saraya, Atsunori;
- Sugishita, Hiroki;
- Nakayama, Manabu;
- Ishikura, Tomoyuki;
- Koseki, Haruhiko;
- Iwama, Atsushi
Publication type:
Article
Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132041
By:
- Wang, Changshan;
- Oshima, Motohiko;
- Sashida, Goro;
- Tomioka, Takahisa;
- Hasegawa, Nagisa;
- Mochizuki-Kashio, Makiko;
- Nakajima-Takagi, Yaeko;
- Kusunoki, Yoichiro;
- Kyoizumi, Seishi;
- Imai, Kazue;
- Nakachi, Kei;
- Iwama, Atsushi
Publication type:
Article
Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study.
Published in:
2020
By:
- Iwahana, Togo;
- Okada, Sho;
- Kanda, Masato;
- Oshima, Motohiko;
- Iwama, Atsushi;
- Matsumiya, Goro;
- Kobayashi, Yoshio
Publication type:
journal article

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