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- Title
Alterations in the Liver Fat Fraction Features Examined by Magnetic Resonance Imaging Following Bariatric Surgery: a Self-Controlled Observational Study.
- Authors
Li, Mengyi; Cao, Di; Liu, Yang; Jin, Lan; Zeng, Na; Wang, Lixue; Zhao, Kaixin; Lv, Han; Zhang, Meng; Zhang, Peng; Yang, Zhenghan; Zhang, Zhongtao
- Abstract
Background: Obesity is a worldwide epidemic leading to non-alcoholic fatty liver disease. Alterations in the liver fat fraction (LFF) assessed by MRI following bariatric surgery is a promising feature; however, few studies have been fully elucidated. Purpose: To determine the alterations in the LFF features following surgery using MRI, to determine the correlation with the clinical non-alcoholic steatohepatitis score (C-NASH score), and to identify the predictive factors for postoperative score changes. Methods: Patients (n = 69) underwent MRI to measure the LFF at baseline and 3 months postoperatively. Paired sample t tests were applied to investigate the alterations in the major parameters. Univariate analyses were performed to evaluate the factors predicting C-NASH score changes after surgery. Results: Compared with the baseline levels, the LFF significantly decreased 3 months postoperatively (P < 0.001). Significant positive correlations were detected between the C-NASH score and LFF levels (P < 0.001). Among the ROC curves for C-NASH score change, the AUC for the ROC curve of LFF was 0.812 (95% CI 0.707, 0.916) and the cut-off value was 6.16%. Weight at baseline was a significant predictive factor for postoperative changes when the C-NASH score was ≥ 3 (P < 0.001). The AUC for the ROC curve of weight was 0.897 (95% CI 0.782, 1.000) and 117 kg was the cut-off value. Conclusions: LFF decreased following bariatric surgery, which predicted C-NASH score changes after surgery. For patients with a higher risk of NASH (score ≥ 3) at baseline and lower preoperative body weight, we noted significantly greater effects of surgery on score change value.
- Subjects
MAGNETIC resonance imaging; BARIATRIC surgery; FATTY liver; RECEIVER operating characteristic curves
- Publication
Obesity Surgery, 2020, Vol 30, Issue 5, p1917
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-020-04415-5