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- Title
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.
- Authors
Linsenmeier, Luise; Mohammadi, Behnam; Wetzel, Sebastian; Puig, Berta; Jackson, Walker S.; Hartmann, Alexander; Uchiyama, Keiji; Sakaguchi, Suehiro; Endres, Kristina; Tatzelt, Jörg; Saftig, Paul; Glatzel, Markus; Altmeppen, Hermann C.
- Abstract
The article presents a study which examines mechanistic and structural aspects affecting the ADAM10-mediated shedding of the prion protein (PrPC). The study involved the production of sPrPG228 antibody for PrP shedding, investigation of genetically modified cellular and murine models, and methods such as immunofluorescence staining, immunohistochemical and histological stainings, and nanoparticle tracking analysis and exosome isolation.
- Subjects
MOLECULAR structure of prions; STRUCTURAL proteomics; IMMUNOFLUORESCENCE; IMMUNOSTAINING; EXOSOMES
- Publication
Molecular Neurodegeneration, 2018, Vol 13, Issue 1, p1
- ISSN
1750-1326
- Publication type
Article
- DOI
10.1186/s13024-018-0248-6