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- Title
Non–high-density lipoprotein cholesterol (non-HDL-C) as a predictor of cardiovascular mortality in patients with end-stage renal disease.
- Authors
Nishizawa, Yoshiki; Shoji, Tetsuo; Kakiya, Ryusuke; Tsujimoto, Yoshihiro; Tabata, Tsutomu; Ishimura, Eiji; Nakatani, Tatsuya; Miki, Takami; Inaba, Masaaki
- Abstract
Non–high-density lipoprotein cholesterol (non-HDL-C) as a predictor of cardiovascular mortality in patients with end-stage renal disease. Background. Patients with end-stage renal disease (ESRD) often show lipid abnormalities that may promote atherosclerosis. Although the standard lipid marker is low-density lipoprotein cholesterol (LDL-C) in official recommendations, the need of fasting blood sampling has prevented routine screening for plasma lipids in hemodialysis patients. Methods. We therefore evaluated the power of non–high-density lipoprotein cholesterol (non–HDL-C) in predialysis (non-fasting) serum as a predictor of cardiovascular mortality in a cohort of 525 hemodialysis patients. Results. During the mean follow-up of 64 months, 120 deaths, including 44 fatal cardiovascular events, occurred. Patients in the highest tertile of non–HDL-C (137 to 285 mg/dL) had a significantly higher risk for cardiovascular mortality (HR, 3.065; 95% CI, 1.357% to 6.925%; P = 0.007) in a univariate Cox analysis. The association between non–HDL-C and cardiovascular mortality remained significant in multivariate Cox models, which included HDL-C, age, gender, duration of hemodialysis, blood pressure, presence of diabetes mellitus, serum albumin, C-reactive protein, and body mass index. Conclusion. Non–HDL-C in predialysis serum was a significant and independent predictor of cardiovascular mortality in hemodialysis patients. Non–HDL-C may be a useful marker for risk assessment in routine practice, although predictive powers of this and the standard fasting LDL-C should be compared in future studies.
- Subjects
LIPOPROTEINS; CARDIOVASCULAR diseases; CHRONIC kidney failure
- Publication
Kidney International Supplement, 2003, Issue 84, p117
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1046/j.1523-1755.63.s84.30.x