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- Title
Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases.
- Authors
Mellgren, K.; Attarbaschi, A.; Abla, O.; Alexander, S.; Bomken, S.; Bubanska, E.; Chiang, A.; Csóka, M.; Fedorova, A.; Kabickova, E.; Kapuscinska-Kemblowska, L.; Kobayashi, R.; Krenova, Z.; Meyer-Wentrup, F.; Miakova, N.; Pillon, M.; Plat, G.; Uyttebroeck, A.; Williams, D.; Wróbel, G.
- Abstract
Peripheral T cell lymphomas (PTCL) are rare in children and adolescents, and data about outcome and treatment results are scarce. The present study is a joint, international, retrospective analysis of 143 reported cases of non-anaplastic PTCL in patients <19 years of age, with a focus on treatment and outcome features. One hundred forty-three patients, between 0.3 and 18.7 years old, diagnosed between 2000 and 2015 were included in the study. PTCL not otherwise specified was the largest subgroup, followed by extranodal NK/T cell lymphoma, hepatosplenic T cell lymphoma (HS TCL), and subcutaneous panniculitis-like T cell lymphoma (SP TCL). Probability of overall survival (pOS) at 5 years for the whole group was 0.56 ± 0.05, and probability of event-free survival was (pEFS) 0.45 ± 0.05. Patients with SP TCL had a good outcome with 5-year pOS of 0.78 ± 0.1 while patients with HS TCL were reported with 5-year pOS of only 0.13 ± 0.12. Twenty-five percent of the patients were reported to have a pre-existing condition, and this group had a dismal outcome with 5-year pOS of 0.29 ± 0.09. The distribution of non-anaplastic PTCL subtypes in pediatric and adolescent patients differs from what is reported in adult patients. Overall outcome depends on the subtype with some doing better than others. Pre-existing conditions are frequent and associated with poor outcomes. There is a clear need for subtype-based treatment recommendations for children and adolescents with PTCL.
- Subjects
LYMPHOMA diagnosis; LYMPHOMAS in children; T-cell lymphoma; LYMPHOMA treatment; PEDIATRIC hematology; ANTINEOPLASTIC agents; COMBINED modality therapy; COMPARATIVE studies; HEMATOPOIETIC stem cell transplantation; INTERNATIONAL relations; RESEARCH methodology; MEDICAL cooperation; HEALTH outcome assessment; PROGNOSIS; RESEARCH; EVALUATION research; DISEASE remission; RETROSPECTIVE studies; THERAPEUTICS
- Publication
Annals of Hematology, 2016, Vol 95, Issue 8, p1295
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s00277-016-2722-y