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- Title
First clinical experiences with perampanel-The Kork experience in 74 patients.
- Authors
Steinhoff, Bernhard J.; Bacher, Matthias; Bast, Thomas; Kornmeier, Reinhold; Kurth, Christoph; Scholly, Julia; Staack, Anke M.; Wisniewski, Ilona
- Abstract
Perampanel ( PER) has been approved for adjunctive treatment of partial-onset seizures in patients age 12 years and older. In Germany, PER was licensed and marketed in September of 2012. At our tertiary referral epilepsy center, a couple of difficult-to-treat patients were awaiting this introduction of PER; therefore, we were able to initiate treatment in many patients within a short period of time. For this report we collected and analyzed the data of the first patients who had been started on add-on PER between September and December of 2012, so that we were able to evaluate at least 6 months of treatment when we made this analysis. At cutoff in June of 2013, 74 patients could be analyzed. Mean age was 38.4 years (range 15-71 years). PER doses ranged from 4 to 14 mg (mean 8.8 mg). All patients took PER once daily at bedtime. Seventy-one patients had focal epileptic seizures; the remaining four patients had Lennox-Gastaut syndrome. Considering the last 3 months of observation compared with baseline, 34 patients (46%) were responders with a reduction of seizure frequency of at least 50%. Ten patients of these (14% of all) were seizure-free. Adverse events were reported in 40 patients (54%). Leading side effects were somnolence (n = 31, 42%) and dizziness (n = 13, 18%), followed by ataxia, irritability, falls, cognitive slowing, and depression in single cases. Six-month retention rate was 70%. Our first clinical experiences with add-on PER in a highly selected group of difficult-to-treat epilepsies are promising.
- Subjects
KEHL (Germany); PYRIDONE; TREATMENT of epilepsy; DRUG dosage; DRUG side effects; DROWSINESS
- Publication
Epilepsia (Series 4), 2014, Vol 55, p16
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/epi.12492