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- Title
H2AFX Polymorphisms Are Associated with Decreased Risk of Diffuse Large B Cell Lymphoma in Koreans.
- Authors
Jin, Xue Mei; Kim, Hee Nam; Shin, Min-Ho; Lee, Il-Kwon; Lee, Ji Shin; Lee, Jae-Hyuk; Kim, Hyeoung-Joon; Choi, Jin-Su; Juhng, Sang Woo; Choi, Chan
- Abstract
Polymorphisms of the H2A histone family member X ( H2AFX) gene have been associated with decreased non-Hodgkin lymphoma (NHL, -417AA) risk and increased breast cancer (1654AG/GG, and -1420GA/AA) risk. We investigated whether H2AFX polymorphisms are associated with the risk of NHL and its subtypes in 573 NHL Korean patients and 721 cancer-free control subjects, using high resolution melting polymerase chain reaction and an automatic sequencer. There was no association between polymorphisms and the risk of overall NHL, all B cell lymphoma, or all T cell lymphoma. However, the -1420 AA genotype was associated with decreased diffuse large B cell lymphoma (DLBCL) risk (OR, 0.65; 95% CI, 0.43-0.97), and there was a trend for allele dose-effect ( p-trend=0.03). The -1187 CC genotype was associated with decreased DLBCL risk with borderline significance (OR, 0.70; 95% CI, 0.48-1.02). There was a trend for an allele dose-effect with borderline significance ( p-trend=0.06). These results suggest that the -1420 AA genotype of H2AFX may be associated with reduced DLBCL risks in the Korean population.
- Subjects
LYMPHOMAS; GENETIC polymorphisms; POLYMERASE chain reaction; T-cell lymphoma; BREAST cancer
- Publication
DNA & Cell Biology, 2011, Vol 30, Issue 12, p1039
- ISSN
1044-5498
- Publication type
Article
- DOI
10.1089/dna.2010.1130