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- Title
ABCB1 C3435T polymorphism and the lipidlowering response in hypercholesterolemic patients on statins: a meta-analysis.
- Authors
Jia Su; Hongyu Xu; Jun Yang; Qinglin Yu; Shujun Yang; Jianjiang Zhang; Qi Yao; Yunyun Zhu; Yuan Luo; Lindan Ji; Yibo Zheng; Jingbo Yu
- Abstract
Background: A number of researches have evaluated the association between the ABCB1 polymorphism and the lipid-lowering response of statins, but the results have been inconclusive. To examine the lipid-lowering efficacy and safety associated with the ABCB1 C3435T polymorphism in hypercholesterolemic patients receiving statin, all available studies were included in this meta-analysis. Methods: A systematic search for eligible studies in the Cochrane library database, Scopus and PubMed was performed. Articles meeting the inclusion criteria were comprehensively reviewed, and the available data were accumulated by the meta-analysis. Results: The results indicated that the comparisons of CC+CT vs. TT were associated with a significant elevation of the serum HDL-C levels after statin treatment (CC+CT vs. TT: MD, 2.46; 95 % CI, 0.36 to 4.55; P = 0.02), and the ABCB1 C3435T variant in homozygotes was correlated with decreases in LDL-C (CC vs. TT: MD, 2.29; 95 % CI, 0.37 to 4.20; P = 0.02) as well as TC (CC vs. TT: MD, 3.05; 95 % CI, 0.58 to 5.53; P = 0.02) in patients treated with statin. However, we did not observe a significant association in the TG group or an association between other genetic models serum lipid parameters. In addition, statin treatment more than 5 months led to a higher risk of muscle toxicity. Conclusions: The evidence from the meta-analysis demonstrated that the ABCB1 C3435T polymorphism may represent a pharmacogenomic biomarker for predicting treatment outcomes in patients on statins and that statin treatment for more than 5 months can increase the risk of myopathy.
- Subjects
GENETIC polymorphism research; STATINS (Cardiovascular agents); DRUG efficacy; PHARMACODYNAMICS; HYPERCHOLESTEREMIA; GENETICS
- Publication
Lipids in Health & Disease, 2015, Vol 14, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/s12944-015-0114-2