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- Title
Interplay between α-synuclein and parkin genes: Insights of Parkinson's disease.
- Authors
Sharma, Kajal; Chib, Shivani; Gupta, Aniket; Singh, Randhir; Chalotra, Rishabh
- Abstract
Parkinson's disease (PD) is a complex and debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. The pathogenesis of PD is intimately linked to the roles of two key molecular players, α-synuclein (α-syn) and Parkin. Understanding the intricate interplay between α-syn and Parkin is essential for unravelling the molecular underpinnings of PD. Their roles in synaptic function and protein quality control underscore their significance in neuronal health. Dysregulation of these processes, as seen in PD, highlights the potential for targeted therapeutic strategies aimed at restoring normal protein homeostasis and mitigating neurodegeneration. Investigating the connections between α-syn, Parkin, and various pathological mechanisms provides insights into the complex web of factors contributing to PD pathogenesis and offers hope for the development of more effective treatments for this devastating neurological disorder. The present compilation provides an overview of their structures, regional and cellular locations, associations, physiological functions, and pathological roles in the context of PD.
- Subjects
PARKINSON'S disease; DOPAMINERGIC neurons; ALPHA-synuclein; PARKIN (Protein); SUBSTANTIA nigra; DOPAMINE receptors; NEUROLOGICAL disorders; HOMEOSTASIS
- Publication
Molecular Biology Reports, 2024, Vol 51, Issue 1, p1
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-024-09520-7