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- Title
Developmental roles of microglia: A window into mechanisms of disease.
- Authors
Anderson, Sarah R.; Vetter, Monica L.
- Abstract
Microglia are engineers of the central nervous system (CNS) both in health and disease. In addition to the canonical immunological roles of clearing damaging entities and limiting the spread of toxicity and death, microglia remodel the CNS throughout life. While they have been extensively studied in disease and injury, due to their highly variable functions, their precise role in these contexts still remains uncertain. Over the past decade, we have greatly expanded our understanding of microglial function, including their essential homeostatic roles during development. Here, we review these developmental roles, identify parallels in disease, and speculate whether developmental mechanisms re‐emerge in disease and injury. Developmental Dynamics 248:98–117, 2019. © 2018 Wiley Periodicals, Inc. Key Findings: Microglia are diverse cells with complex roles in development and disease.Microglia remodel the CNS during development by regulating proliferation, differentiation, neuronal migration, and neuronal integration into circuits.There are transcriptionally distinct subsets of microglia present in development and disease with overlapping gene expression.Developmental microglia have roles that parallel those found in disease.Microglia utilize some of the same molecular pathways in development and disease.
- Publication
Developmental Dynamics, 2019, Vol 248, Issue 1, p98
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.1